The show-me state is no stranger to rapidly changing weather conditions.
During the transition period between seasons, we can expect a wide range of weather patterns from freezing temperatures one day, to 70s a few days later.
But what impact does this quick change have on our health?
None, according to Dr. Donna McCluskey of Capital Region Medical Center.
"Generally weather change doesn't make you sick, it doesn't decrease your immunity at all but it makes us go indoors and then we're more exposed to germs and being around germs, so we often start getting ill more often then," said McCluskey.
She said allergies can cause common cold like symptoms this time of year, too.
"The seasonal changes...things are blooming and when the harvest is coming in and farmers are out and about and the leaves are blowing...that triggers allergies and asthmatics are often affected by the weather changes."
You can decrease your risk of getting sick this season by washing your hands frequently, drinking plenty of water, and getting an adequate amount of sleep each day.
The most at risk of falling ill are children and the elderly, and those with pre-existing illnesses.
If you're starting to feel run down?
"Make sure you're getting plenty of rest, plenty of fluids, and taking time to let your body heal itself and not stay run down by trying to overdo," said McCluskey.
Dr. McCluskey recommends getting your flu shot before winter hits.